Searchable abstracts of presentations at key conferences in oncology

oa0001p045 | (1) | PacRim7

Single-cell transcriptomics reveals marked heterogeneity for intrinsic molecular subtype and cellular function in estrogen receptor positive breast cancer

Roden Daniel , Wu Sunny , Harvey Kate , Chan Chia-Ling , Al-Eryani Ghamdan , Cazet Aurelie , Lim Elgene , Swarbrick Alexander

Breast cancer is a heterogeneous disease that can be classified into a number of molecular subtypes that predict prognosis and influence clinical treatment. Cellular heterogeneity is also evident within breast cancers and plays a key role in their development, evolution and metastatic progression. How clinical heterogeneity relates to cellular heterogeneity is poorly understood. We have approached this question using single-cell RNA-Seq on 1000s of individual cells from well-e...